Original Research (Original Article) 


The anticancer effect of Graviola on PANC1 cancer cells

Mai G. Awad, Ramadan A. Ali, Dalia D. Abd El Monem, Mohammed A. El Magd.

Abstract
This in vitro study was conducted to evaluate the anticancer effect of Graviola leaves extract on the pancreatic cancer cells, PANC1. MTT assay was used to assess the effect of different concentrations of Graviola leaves extract on the cell viability of human PANC1 cells following 24 h incubation. The obtained results revealed a potent cytotoxic effect for Graviola leaves extract on PANC1 cells with IC50 values of 98.62 5.23 g/ml. This anti-cancer effect of Graviola leaves extract accompanied with apoptosis as evidenced by significant increases in the mRNA levels of the two apoptotic markers (caspase3 and Bax) and significant decreases in the mRNA levels of the anti-apoptotic marker (Bcl2). These data conclude that Graviola leaves extract has a potent anti-cancer effect against PANC1 cells and this effect is accompanied by apoptosis.

Key words: Graviola leaf extract; Anticancer; PANC1; Apoptosis


 
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How to Cite this Article
Pubmed Style

MGA, Ali RA, Monem DDAE, Magd MAE. The anticancer effect of Graviola on PANC1 cancer cells. AJMS. 2020; 3(1): 15-17. doi:10.5455/ajms.30


Web Style

MGA, Ali RA, Monem DDAE, Magd MAE. The anticancer effect of Graviola on PANC1 cancer cells. http://www.ajms.tk/?mno=90436 [Access: March 30, 2020]. doi:10.5455/ajms.30


AMA (American Medical Association) Style

MGA, Ali RA, Monem DDAE, Magd MAE. The anticancer effect of Graviola on PANC1 cancer cells. AJMS. 2020; 3(1): 15-17. doi:10.5455/ajms.30



Vancouver/ICMJE Style

MGA, Ali RA, Monem DDAE, Magd MAE. The anticancer effect of Graviola on PANC1 cancer cells. AJMS. (2020), [cited March 30, 2020]; 3(1): 15-17. doi:10.5455/ajms.30



Harvard Style

, M. G. A., Ali, . R. A., Monem, . D. D. A. E. & Magd, . M. A. E. (2020) The anticancer effect of Graviola on PANC1 cancer cells. AJMS, 3 (1), 15-17. doi:10.5455/ajms.30



Turabian Style

, Mai G. Awad, Ramadan A. Ali, Dalia D. Abd El Monem, and Mohammed A. El Magd. 2020. The anticancer effect of Graviola on PANC1 cancer cells. Arabian journal of medical sciences, 3 (1), 15-17. doi:10.5455/ajms.30



Chicago Style

, Mai G. Awad, Ramadan A. Ali, Dalia D. Abd El Monem, and Mohammed A. El Magd. "The anticancer effect of Graviola on PANC1 cancer cells." Arabian journal of medical sciences 3 (2020), 15-17. doi:10.5455/ajms.30



MLA (The Modern Language Association) Style

, Mai G. Awad, Ramadan A. Ali, Dalia D. Abd El Monem, and Mohammed A. El Magd. "The anticancer effect of Graviola on PANC1 cancer cells." Arabian journal of medical sciences 3.1 (2020), 15-17. Print. doi:10.5455/ajms.30



APA (American Psychological Association) Style

, M. G. A., Ali, . R. A., Monem, . D. D. A. E. & Magd, . M. A. E. (2020) The anticancer effect of Graviola on PANC1 cancer cells. Arabian journal of medical sciences, 3 (1), 15-17. doi:10.5455/ajms.30