Original Research (Original Article) 


Adiponectin as a potential biomarker of diabetic nephropathy

Ayman O. EL-Zarka, Aida H. Soliman, Sahar S. Bessa, Tarek M. Mohamed.

Abstract
Diabetic nephropathy (DN) is a progressive kidney disease associated with diabetes mellitus that may lead to end-stage renal disease. Adiponectin (ADP) is a protein hormone produced by white adipose tissue and has vasoprotective properties. Adiponectin level attributes to and associates with diabetic complications. Herein, we assess the potentiality of detecting ADP level as a DN marker. This study included sixty age- and sex- matched subjects which were subdivided into three groups: twenty healthy (control) subjects, twenty type 2 diabetes patients with nephropathy (microalbuminuria 30-300 mg/dL), and twenty type 2 diabetes patients without nephropathy (normoalbuminuria <30 mg/dL). Mean serum ADP levels were significantly increased in all patients with type 2 diabetes with or without nephropathy as compared to the control group with higher levels in those with nephropathy. Serum ADP levels were positively correlated with fasting blood glucose, glycosylated hemoglobin (HbA1c), microalbuminuria, serum creatinine and urea.The most independent risk factors for occurrence of microvascular complications may reflect the role of ADP as a predictor and prognostic marker of DN among patients with type 2 diabetes.

Key words: Diabetic nephropathy; Adiponectin; HbA1c; microalbuminuria


 
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How to Cite this Article
Pubmed Style

EL-Zarka AO, Soliman AH, Bessa SS, Mohamed TM, . Adiponectin as a potential biomarker of diabetic nephropathy. AJMS. 2018; 1(1): 7-13. doi:10.5455/ajms.1


Web Style

EL-Zarka AO, Soliman AH, Bessa SS, Mohamed TM, . Adiponectin as a potential biomarker of diabetic nephropathy. http://www.ajms.tk/?mno=68 [Access: November 16, 2018]. doi:10.5455/ajms.1


AMA (American Medical Association) Style

EL-Zarka AO, Soliman AH, Bessa SS, Mohamed TM, . Adiponectin as a potential biomarker of diabetic nephropathy. AJMS. 2018; 1(1): 7-13. doi:10.5455/ajms.1



Vancouver/ICMJE Style

EL-Zarka AO, Soliman AH, Bessa SS, Mohamed TM, . Adiponectin as a potential biomarker of diabetic nephropathy. AJMS. (2018), [cited November 16, 2018]; 1(1): 7-13. doi:10.5455/ajms.1



Harvard Style

EL-Zarka, A. O., Soliman, . A. H., Bessa, . S. S., Mohamed, . T. M. & (2018) Adiponectin as a potential biomarker of diabetic nephropathy. AJMS, 1 (1), 7-13. doi:10.5455/ajms.1



Turabian Style

EL-Zarka, Ayman O., Aida H. Soliman, Sahar S. Bessa, Tarek M. Mohamed, and . 2018. Adiponectin as a potential biomarker of diabetic nephropathy. Arabian journal of medical sciences, 1 (1), 7-13. doi:10.5455/ajms.1



Chicago Style

EL-Zarka, Ayman O., Aida H. Soliman, Sahar S. Bessa, Tarek M. Mohamed, and . "Adiponectin as a potential biomarker of diabetic nephropathy." Arabian journal of medical sciences 1 (2018), 7-13. doi:10.5455/ajms.1



MLA (The Modern Language Association) Style

EL-Zarka, Ayman O., Aida H. Soliman, Sahar S. Bessa, Tarek M. Mohamed, and . "Adiponectin as a potential biomarker of diabetic nephropathy." Arabian journal of medical sciences 1.1 (2018), 7-13. Print. doi:10.5455/ajms.1



APA (American Psychological Association) Style

EL-Zarka, A. O., Soliman, . A. H., Bessa, . S. S., Mohamed, . T. M. & (2018) Adiponectin as a potential biomarker of diabetic nephropathy. Arabian journal of medical sciences, 1 (1), 7-13. doi:10.5455/ajms.1