Original Research (Original Article) 


Naringenin and Hesperidin ameliorate iron oxide nanoparticles toxicity in rat liver

Abeer A. El-Sayed, Mohamed M. Hussein, Aida H. Soliman.

Abstract
Background: Although, iron oxide nanoparticles (IONs) have some beneficial effects in medical imaging for disease diagnosis and drug delivery for cancer treatment, they accumulated in the hepatocytes, thereby leading to oxidative stress-induced liver damage. Objectives: We investigated the possible protective effect of naringenin (Nar) and hesperidin (Hes) against IONs-induced liver toxicity in rats. Materials and methods: A total number of 70 white male Sprague-Dawley rats randomly assigned into seven groups: group 1 (normal control), group 2 (treated with 20 mg/kg Nar), group 3 (given 15 mg/kg Hes), group 4 (received 150 mg/kg IONs), group 5 (IONs + Nar), group 6 (IONs + Hes), and group 7 (IONs + Nar + Hes). All treatments were given orally by stomach gavage for 30 days. The evaluated parameters included liver function markers, biochemical assays [antioxidant markers (SOD, CAT and GSH), and lipid peroxidation (MDA)], gene expression of SOD and CAT, and histopathology of liver tissues. Results: In IONs-treated group, serum levels of AST, ALT, total and direct bilirubin, and liver MDA contents were significantly increased while serum level of albumin, and mRNAs levels and enzyme activities of SOD, CAT, and GSH levels in liver were significantly decreased comparing to the normal control group. Moreover, administration of IONs led to hydropic degeneration with congestion of the central vein and mononuclear cells infiltration. However, treatment with Nar and Hes restored these disrupted parameters and improved hepatic tissues damage and function to level comparable to that of the control. Conclusion: Using high concentration of IONs could cause oxidative liver damage as evidenced by high ROS, less antioxidant activities, damage to hepatocyte and elevation of liver damage enzymes and this adverse effect was reversed by Nar and Hes.

Key words: Naringenin; Hesperidin; iron oxide nanoparticles;Antioxidant; liver toxicity


 
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How to Cite this Article
Pubmed Style

El-Sayed AA, Hussein MM, Soliman AH, . Naringenin and Hesperidin ameliorate iron oxide nanoparticles toxicity in rat liver. AJMS. 2018; 1(1): 26-30. doi:10.5455/ajms.5


Web Style

El-Sayed AA, Hussein MM, Soliman AH, . Naringenin and Hesperidin ameliorate iron oxide nanoparticles toxicity in rat liver. http://www.ajms.tk/?mno=4602 [Access: November 16, 2018]. doi:10.5455/ajms.5


AMA (American Medical Association) Style

El-Sayed AA, Hussein MM, Soliman AH, . Naringenin and Hesperidin ameliorate iron oxide nanoparticles toxicity in rat liver. AJMS. 2018; 1(1): 26-30. doi:10.5455/ajms.5



Vancouver/ICMJE Style

El-Sayed AA, Hussein MM, Soliman AH, . Naringenin and Hesperidin ameliorate iron oxide nanoparticles toxicity in rat liver. AJMS. (2018), [cited November 16, 2018]; 1(1): 26-30. doi:10.5455/ajms.5



Harvard Style

El-Sayed, A. A., Hussein, . M. M., Soliman, . A. H. & (2018) Naringenin and Hesperidin ameliorate iron oxide nanoparticles toxicity in rat liver. AJMS, 1 (1), 26-30. doi:10.5455/ajms.5



Turabian Style

El-Sayed, Abeer A., Mohamed M. Hussein, Aida H. Soliman, and . 2018. Naringenin and Hesperidin ameliorate iron oxide nanoparticles toxicity in rat liver. Arabian journal of medical sciences, 1 (1), 26-30. doi:10.5455/ajms.5



Chicago Style

El-Sayed, Abeer A., Mohamed M. Hussein, Aida H. Soliman, and . "Naringenin and Hesperidin ameliorate iron oxide nanoparticles toxicity in rat liver." Arabian journal of medical sciences 1 (2018), 26-30. doi:10.5455/ajms.5



MLA (The Modern Language Association) Style

El-Sayed, Abeer A., Mohamed M. Hussein, Aida H. Soliman, and . "Naringenin and Hesperidin ameliorate iron oxide nanoparticles toxicity in rat liver." Arabian journal of medical sciences 1.1 (2018), 26-30. Print. doi:10.5455/ajms.5



APA (American Psychological Association) Style

El-Sayed, A. A., Hussein, . M. M., Soliman, . A. H. & (2018) Naringenin and Hesperidin ameliorate iron oxide nanoparticles toxicity in rat liver. Arabian journal of medical sciences, 1 (1), 26-30. doi:10.5455/ajms.5