Original Research (Original Article) 


Effect of naringenin and hesperidin in amelioration of copper oxid nanoparticles toxicity in rat liver

Radwa S. Eid, Mohamed M. Hussein, Aida H. Soliman.

Abstract
Background: Although copper oxide nanoparticles (CuO NPs) are used in many industrial and manufacturing processes, they cause oxidative stress-induced toxicity.
Objectives: Here, we investigated the potential ameliorative effect for the two flavonoids naringenin (Nar) and hesperidin (Hes), which have a potent antioxidant activity, against CuO NPs-induced toxicities in rat liver.
Materials and methods: Sprague-dawly rats (n = 70, weight = 150-200g) were divided into seven groups (n = 10 per group): normal control (G1), Nar (20 mg/kg)-treated group (G2): Hes (15 mg/kg)-treated (G3), CuO NPs (5 mg/kg)- treated (G4), CuO NPs+ Nar-treated (G5), CuO NPs+Hes (G6), and CuO NPs+Nar+Hes (G7).
Results: A significant increase of ALT, AST and ALP enzymes activities as well as bilirubin content (total, direct) and MDA liver content was detected in CuO NPs (G4) administrated group indicating liver damage. This hepatic damage was confirmed by other biochemical and molecular results which denoted a significant decrease in total protein, albumin, GSH level, SOD, CAT activities and SOD, CAT mRNA level in this group. Administration of Nar and/or Hes alleviated this toxic effect and therefore, Nar and/or could improve the damaged liver tissues and the associated disrupted function that induced by CuO NPs toxicity.
Conclusion: The results suggest that Nar and Hes may be appropriate for clinical application in the treatment of liver disorders induced by CuO toxicity.

Key words: Copper oxide nanoparticle, naringenin, hesperidin, antioxidant


 
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How to Cite this Article
Pubmed Style

Eid RS, Hussein MM, Soliman AH, . Effect of naringenin and hesperidin in amelioration of copper oxid nanoparticles toxicity in rat liver. AJMS. 2018; 1(1): 14-18. doi:10.5455/ajms.3


Web Style

Eid RS, Hussein MM, Soliman AH, . Effect of naringenin and hesperidin in amelioration of copper oxid nanoparticles toxicity in rat liver. http://www.ajms.tk/?mno=3754 [Access: November 16, 2018]. doi:10.5455/ajms.3


AMA (American Medical Association) Style

Eid RS, Hussein MM, Soliman AH, . Effect of naringenin and hesperidin in amelioration of copper oxid nanoparticles toxicity in rat liver. AJMS. 2018; 1(1): 14-18. doi:10.5455/ajms.3



Vancouver/ICMJE Style

Eid RS, Hussein MM, Soliman AH, . Effect of naringenin and hesperidin in amelioration of copper oxid nanoparticles toxicity in rat liver. AJMS. (2018), [cited November 16, 2018]; 1(1): 14-18. doi:10.5455/ajms.3



Harvard Style

Eid, R. S., Hussein, M. . M. ., Soliman, A. . H. . & (2018) Effect of naringenin and hesperidin in amelioration of copper oxid nanoparticles toxicity in rat liver. AJMS, 1 (1), 14-18. doi:10.5455/ajms.3



Turabian Style

Eid, Radwa S., Mohamed M. Hussein, Aida H. Soliman, and . 2018. Effect of naringenin and hesperidin in amelioration of copper oxid nanoparticles toxicity in rat liver. Arabian journal of medical sciences, 1 (1), 14-18. doi:10.5455/ajms.3



Chicago Style

Eid, Radwa S., Mohamed M. Hussein, Aida H. Soliman, and . "Effect of naringenin and hesperidin in amelioration of copper oxid nanoparticles toxicity in rat liver." Arabian journal of medical sciences 1 (2018), 14-18. doi:10.5455/ajms.3



MLA (The Modern Language Association) Style

Eid, Radwa S., Mohamed M. Hussein, Aida H. Soliman, and . "Effect of naringenin and hesperidin in amelioration of copper oxid nanoparticles toxicity in rat liver." Arabian journal of medical sciences 1.1 (2018), 14-18. Print. doi:10.5455/ajms.3



APA (American Psychological Association) Style

Eid, R. S., Hussein, M. . M. ., Soliman, A. . H. . & (2018) Effect of naringenin and hesperidin in amelioration of copper oxid nanoparticles toxicity in rat liver. Arabian journal of medical sciences, 1 (1), 14-18. doi:10.5455/ajms.3