Review Article 


Therapeutic implications of autophagy in cancer treatment

Samah Nasr Eldeen, Mohammed El Magd, Abeer khamis, Wafaa Ibrahim, Afrah Salama.

Abstract
Autophagy is a survival process in which a cell preserves its own components in case of nutrient deprivation by recycling its digested contents and cannibalizing itself. It is characterized by the double membrane autophagosomes formation and it has a fantastic role in cancer treatment by many mechanisms. Interestingly, Autophagy has a great effect in the treatment of many diseases by different mechanisms. Autophagy has been included as a treatment mechanism of various diseases by cell losing, such as degenerative diseases of the muscle and nervous system. It has been found abundant of autophagic vacuoles inside the damaged cells in many of these degenerative disorders. Autophagy can help both living cells and cancer cells to survive so when the strategy of the treatment of cancer decreases autophagy process of cancer cells, it prevents them to survive and divide. In this review, we illustrated the definition of autophagy, autophagic pathways, therapeutic implications of autophagy, the relationship between autophagy and cell death, inflammation, and necrosis.

Key words: Cancer, Autophagy, inflammation, necrosis


 
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How to Cite this Article
Pubmed Style

Eldeen SN, Magd ME, khamis A, Ibrahim W, Salama A, . Therapeutic implications of autophagy in cancer treatment. AJMS. 2019; 2(2): 27-29. doi:10.5455/ajms.19


Web Style

Eldeen SN, Magd ME, khamis A, Ibrahim W, Salama A, . Therapeutic implications of autophagy in cancer treatment. http://www.ajms.tk/?mno=25589 [Access: July 19, 2019]. doi:10.5455/ajms.19


AMA (American Medical Association) Style

Eldeen SN, Magd ME, khamis A, Ibrahim W, Salama A, . Therapeutic implications of autophagy in cancer treatment. AJMS. 2019; 2(2): 27-29. doi:10.5455/ajms.19



Vancouver/ICMJE Style

Eldeen SN, Magd ME, khamis A, Ibrahim W, Salama A, . Therapeutic implications of autophagy in cancer treatment. AJMS. (2019), [cited July 19, 2019]; 2(2): 27-29. doi:10.5455/ajms.19



Harvard Style

Eldeen, S. N., Magd, M. E., khamis, A., Ibrahim, W., Salama, A. & (2019) Therapeutic implications of autophagy in cancer treatment. AJMS, 2 (2), 27-29. doi:10.5455/ajms.19



Turabian Style

Eldeen, Samah Nasr, Mohammed El Magd, Abeer khamis, Wafaa Ibrahim, Afrah Salama, and . 2019. Therapeutic implications of autophagy in cancer treatment. Arabian journal of medical sciences, 2 (2), 27-29. doi:10.5455/ajms.19



Chicago Style

Eldeen, Samah Nasr, Mohammed El Magd, Abeer khamis, Wafaa Ibrahim, Afrah Salama, and . "Therapeutic implications of autophagy in cancer treatment." Arabian journal of medical sciences 2 (2019), 27-29. doi:10.5455/ajms.19



MLA (The Modern Language Association) Style

Eldeen, Samah Nasr, Mohammed El Magd, Abeer khamis, Wafaa Ibrahim, Afrah Salama, and . "Therapeutic implications of autophagy in cancer treatment." Arabian journal of medical sciences 2.2 (2019), 27-29. Print. doi:10.5455/ajms.19



APA (American Psychological Association) Style

Eldeen, S. N., Magd, M. E., khamis, A., Ibrahim, W., Salama, A. & (2019) Therapeutic implications of autophagy in cancer treatment. Arabian journal of medical sciences, 2 (2), 27-29. doi:10.5455/ajms.19