Original Research (Original Article) 


Synthesis and Anti-microbial Activities of Some (aryl)-N'-benzylidene-2-hydroxybenzohydrazide derivatives

EL-Refaie Kenawy, Abd EL-Basset Shokr, Nayera A.M. Abdel-Wahed, Tarek M Zied.

Abstract
In order to study new bioactive compounds, we carried out certain chemical transformations of salicylic acid hydrazide through reaction with a set of aromatic aldehydess (benzaldehyde, p-chloro-benzaldehyde , p-methoxy-benzaldehyde , N , N'di methyl- benzaldehyde) in boiling methanol; and in the presence of a catalytic amount of piperidine under reflux conditions to yield the corresponding derivatives in moderately good yields. The corresponding thiazolidinone derivatives were obtained by the treatment with thioglycolic acid under reflux conditions. The reactivity of salicyloyl hydrazide towards the reaction with some nucleophiles was investigated by reaction with formamide, urea, acetamide and benzyl. The produced derivatives were screened for their anti-microbial activities. Salicylic acid hydrazide was successfully accommodated subunits of thiazolidine-4-ones or oroxadiazin or pyrimidin affording a set of derivatives which prove their utility in medicinal chemistry ; as they showed a moderate to high antimicrobial properties proving the synthetic utility of salicylic acid hydrazide in constructing new heterocycles of possible expected therapeutic relevance. The same molecular hybrid template may afford more potent scaffolds upon the incorporation of more effective substituents based on the highly biological profile of salicylic acid hydrazide itself.

Key words: Methyl Salicylate, Asprine, Salicylic Hydrazide, Anti-bacterial activity, Thiazolidinone , Aromatic Aldehydes, Anti-fungal activity


 
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How to Cite this Article
Pubmed Style

Kenawy E, Shokr AE, Abdel-Wahed NA, Zied TM, . Synthesis and Anti-microbial Activities of Some (aryl)-N'-benzylidene-2-hydroxybenzohydrazide derivatives . AJMS. 2018; 1(1): 19-25. doi:10.5455/ajms.4


Web Style

Kenawy E, Shokr AE, Abdel-Wahed NA, Zied TM, . Synthesis and Anti-microbial Activities of Some (aryl)-N'-benzylidene-2-hydroxybenzohydrazide derivatives . http://www.ajms.tk/?mno=2508 [Access: November 16, 2018]. doi:10.5455/ajms.4


AMA (American Medical Association) Style

Kenawy E, Shokr AE, Abdel-Wahed NA, Zied TM, . Synthesis and Anti-microbial Activities of Some (aryl)-N'-benzylidene-2-hydroxybenzohydrazide derivatives . AJMS. 2018; 1(1): 19-25. doi:10.5455/ajms.4



Vancouver/ICMJE Style

Kenawy E, Shokr AE, Abdel-Wahed NA, Zied TM, . Synthesis and Anti-microbial Activities of Some (aryl)-N'-benzylidene-2-hydroxybenzohydrazide derivatives . AJMS. (2018), [cited November 16, 2018]; 1(1): 19-25. doi:10.5455/ajms.4



Harvard Style

Kenawy, E. . ., Shokr, A. E. ., Abdel-Wahed, N. A., Zied, T. M. & (2018) Synthesis and Anti-microbial Activities of Some (aryl)-N'-benzylidene-2-hydroxybenzohydrazide derivatives . AJMS, 1 (1), 19-25. doi:10.5455/ajms.4



Turabian Style

Kenawy, EL-Refaie , Abd EL-Basset Shokr, Nayera A.M. Abdel-Wahed, Tarek M Zied, and . 2018. Synthesis and Anti-microbial Activities of Some (aryl)-N'-benzylidene-2-hydroxybenzohydrazide derivatives . Arabian journal of medical sciences, 1 (1), 19-25. doi:10.5455/ajms.4



Chicago Style

Kenawy, EL-Refaie , Abd EL-Basset Shokr, Nayera A.M. Abdel-Wahed, Tarek M Zied, and . "Synthesis and Anti-microbial Activities of Some (aryl)-N'-benzylidene-2-hydroxybenzohydrazide derivatives ." Arabian journal of medical sciences 1 (2018), 19-25. doi:10.5455/ajms.4



MLA (The Modern Language Association) Style

Kenawy, EL-Refaie , Abd EL-Basset Shokr, Nayera A.M. Abdel-Wahed, Tarek M Zied, and . "Synthesis and Anti-microbial Activities of Some (aryl)-N'-benzylidene-2-hydroxybenzohydrazide derivatives ." Arabian journal of medical sciences 1.1 (2018), 19-25. Print. doi:10.5455/ajms.4



APA (American Psychological Association) Style

Kenawy, E. . ., Shokr, A. E. ., Abdel-Wahed, N. A., Zied, T. M. & (2018) Synthesis and Anti-microbial Activities of Some (aryl)-N'-benzylidene-2-hydroxybenzohydrazide derivatives . Arabian journal of medical sciences, 1 (1), 19-25. doi:10.5455/ajms.4